Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study

Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study 

Karen Ritchie,  Isabelle Carrière, Sarah Gregory, Tam Watermeyer, Samuel Danso, Li Su, Craig W Ritchie, John T O’Brien

Journal of Neurology, Neurosurgery and Psychiatry. 2020

DOI: http://dx.doi.org/10.1136/jnnp-2020-323823

Summary 

This study explored the links between childhood trauma, depression, adult cognitive functioning and risk of dementia.

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Associations between midlife chronic conditions and medication use with anxiety and depression: A cross-sectional analysis of the PREVENT Dementia study

Lucy E Stirland , Sarah Gregory, Tom C Russ, Craig W Ritchie, Graciela Muniz-Terrera
Journal of Comorbidity. 2020
10.1177/1471301218789307

Summary

There is evidence to suggest that brain health is associated with multimorbidity, polypharmacy, depression and anxiety. This study aimed to investigate the interactions between these four-potential dementia-risk factors (depression, anxiety, multimorbidity and polypharmacy) at mid-life.

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Research participants as collaborators: Background, experience and policies from the PREVENT Dementia and EPAD programmes

Sarah Gregory, Katie Wells, Kate Forysth, Cate Latto, Helen Szyra, Stina Saunders, Craig W Ritchie, Richard Milne
Dementia Journal. 2018
10.1177/1471301218789307

Perspectives on Communicating Biomarker-Based Assessments of Alzheimer’s Disease to Cognitively Healthy Individuals.

Milne R, Bunnik E, Diaz A, Richard E, Badger S, Gove D, Georges J, Fauria K, Molinuevo JL, Wells K, Ritchie C.
Journal of Alzheimer’s Disease. 2018
10.3233/JAD-170813

PREVENT participants took part in organised group discussions around the benefits, harms and rights of an individual finding out information from biological measurements that may inform their personal risk of Alzheimer’s disease.

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At, with and beyond risk: expectations of living with the possibility of future dementia.

Milne R, Diaz A, Badger S, Bunnik E, Fauria K, Wells K.
Sociology of health & illness. 2017.
10.1111/1467-9566.12731

Focus groups were held with PREVENT participants to develop discussions around disclosure of dementia risk.

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The PREVENT research programme–a novel research programme to identify and manage midlife risk for dementia: the conceptual framework.

Ritchie CW, Wells K, Ritchie K.
International Review of Psychiatry. 2013
10.3109/09540261.2013.869195

This article outlines the vision of the PREVENT study and how, through in depth study of people in their mid-life, PREVENT can generate novel evidence to inform future interventional trials and improve future care.

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