Publications

The PREVENT Dementia Programme has a number of publications which have been published across a range of peer reviewed journals and can be accessed through the links in the categories below.

Imaging - View all [16]

Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study

Maria-Eleni Douvani, Coco Newton, Elijah Mak, Audrey Low, Graciela Muniz Terrera, Guy B. Williams, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare E. Mackay, Ivan Koychev, Karen Ritchie, Craig W. Ritchie, Li Su, John T O’Brien.

Journal of Neurology (2022)

DOI: http://dx.doi.org/10.1136/jnnp-2021-32746

Summary

Structural brain alterations such as volume loss in brain structures like the hippocampus, or thinning of the brain cortex typically occur  before cognitive symptomatology in people who will later develop dementia. In this study we investigated whether middle-aged participants in the PREVENT-Dementia study at risk of future dementia based on their genetic or cardiovascular risk demonstrated prominent structural brain alterations. Genetic risk was not associated with changes in brain volume even in the hippocampal subfields or with cortical thinning. A higher cardiovascular risk though (CAIDE dementia risk score) incorporating information on age, sex, education, blood pressure, cholesterol, body mass index and activity was associated with cortical thinning. This study highlights that in midlife, cardiovascular risk and not genetic risk for dementia is related to patterns of brain changes which are reminiscent of the patterns observed in dementia.​

Cognition - View all [6]

Memory assessment and dementia risk in the PREVENT Study

Mario A. Parra, Graciela Muniz-Terrera, Samuel O. Danso, Karen Ritchie, Craig W Ritchie.
Alzheimer’s & Dementia (2021)

DOI: https://doi/epdf/10.1002/alz.055104

Summary
The study assessed relational (face-name) and conjunctional (object-colour) memory markers in 183 participants from the PREVENT Dementia programme. Conjunctive measures included: the 4 Mountains test, Virtual reality supermarket task, name-face association test and the relational measure: the visual short term memory binding test were used to assess cognition. There were no significant differences in performance across different risk groups.

Other - View all [7]

Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study

Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study 

Karen Ritchie,  Isabelle Carrière, Sarah Gregory, Tam Watermeyer, Samuel Danso, Li Su, Craig W Ritchie, John T O’Brien

Journal of Neurology, Neurosurgery and Psychiatry. 2020

DOI: http://dx.doi.org/10.1136/jnnp-2020-323823

Summary 

This study explored the links between childhood trauma, depression, adult cognitive functioning and risk of dementia.

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