Publications

The PREVENT Dementia Programme has a number of publications which have been published across a range of peer reviewed journals and can be accessed through the links in the categories below.

Imaging - View all [10]

Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study

Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study 

Karen Ritchie,  Isabelle Carrière, Sarah Gregory, Tam Watermeyer, Samuel Danso, Li Su, Craig W Ritchie, John T O’Brien

Journal of Neurology, Neurosurgery and Psychiatry. 2020

DOI: http://dx.doi.org/10.1136/jnnp-2020-323823

Summary 

This study explored the links between childhood trauma, depression, adult cognitive functioning and risk of dementia.

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Cognition - View all [5]

Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals

Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W. Ritchie, Li Su, Graciela Muniz-Terrera & John T. O’Brien

Journal of Neurology. 2021

DOI: https://doi.org/10.1007/s00415-020-10383-8

Summary
Cardiovascular factors have a strong association with Alzheimer’s disease (AD) and brain atrophy. However, until recently, there has been limited longitudinal research in cognitive healthy middle-aged adults investigating these links. A recent PREVENT Dementia study used data from 167 participants in the PREVENT London cohort, to investigate associations between the CAIDE (Cardiovascular Risk Factors, Aging, and Dementia) score and structural MRI scans at both baseline and 2-year follow up. Participants in the high-risk group (i.e., those with a CAIDE score above 6) were on average, found to have a greater rate of brain atrophy. However, to identify the specific regions and structures driving this atrophy pattern, additional analysis was conducted using voxel based morphometry (VBM).

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Other - View all [6]

Associations between midlife chronic conditions and medication use with anxiety and depression: A cross-sectional analysis of the PREVENT Dementia study

Lucy E Stirland , Sarah Gregory, Tom C Russ, Craig W Ritchie, Graciela Muniz-Terrera
Journal of Comorbidity. 2020
10.1177/1471301218789307

Summary

There is evidence to suggest that brain health is associated with multimorbidity, polypharmacy, depression and anxiety. This study aimed to investigate the interactions between these four-potential dementia-risk factors (depression, anxiety, multimorbidity and polypharmacy) at mid-life.

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