Prevent Dementia is led by Professor Craig Ritchie of the University of Edinburgh, with leading investigators at each of our study sites. The primary focus of the study is to recruit 700 volunteers into this longitudinal cohort study aiming to identify risk factors for dementia in mid-life. This cohort also feeds in to the European Prevention of Alzheimer's Dementia (EPAD) project as well as the TriBEKA Imaging Platform.
European Prevention of Alzheimer’s Dementia
TriBEKA Imaging Platform
In addition to the primary project, we have two working groups that focus on genetics and imaging.
We have a number of sub-studies which have resulted from various collaborations with other academic institutions across the UK.
Led by Professor John O'Brien this study involves 300 Prevent Dementia participants undergoing PET-CT scanning to investigate levels of brain amyloid in mid-life.Professor John O’Brien’s biography
Led by Dr Tom MacGillivray this study invites all participants in Edinburgh to undergo retinal eye imaging using Optical Coherence Tomography (OCT).Dr Tom MacGillivray’s biography
Professor Alison Wray from Cardiff University recruits participants from the London, Edinburgh, Oxford and Cambridge sites. Participants are asked to complete an assessment which assesses whether it is possible to use language as a future indicator of dementia risk.Professor Alison Wray’s biography
Sofia de la Fuente Garcia conducted a Medical Research Council funded PhD project investigating whether features used in dialogue can be used to predict dementia onset in later life. Sofia will initially be recruiting participa.Medical Research Council
Based at the University of Oxford this study explored the usability of two mobile technologies developed to track cognition and function. The first is a smartphone-based application and the second measures the interactions between a smartwatch worn by participants and Bluetooth beacons positioned around their homes to assess their level of function and activity and their ability to navigate their environment.Medical Research Council
Engaging with Research: Barriers, Facilitators and Motivators for participating in Dementia prevention research:
The overall aim of this project is to explore the motives, facilitators, and organizational structural barriers to participation in dementia prevention/risk-reduction research in healthy middle-aged adults who are under-represented in research. The information gained from this study may help researchers to modify their research design and recruitment strategies in order to best support the inclusion of an equitable research population.
To achieve this objective this pilot project will conduct a qualitative interview sub-study with PREVENT Study participants, who are healthy middle-aged adults currently participating in prevention/risk reduction research.
ENtorhinal CoRtex Structure and Function in PREVENT (ENCRYPT)
ENCRYPT is investigating the function of the entorhinal cortex (EC), a brain region responsible for functions such as navigation, orientation, and memory of landmarks. The EC also happens to be one of the first regions affected by the pathology of Alzheimer’s disease (AD). Thus, examining EC navigation functions in people at different levels of risk of developing AD can offer us crucial information about the earliest signs of dementia onset, and the best ways to detect and monitor them.
All participants complete a novel virtual reality navigation task and for some participants, an additional high-resolution 7T MRI brain scan is completed.
For requests to access PREVENT data please complete the following data access request form. Alternatively if you have any questions prior to completing the form please complete the contact form below.