The midlife cognitive profiles of adults at high risk of late-onset Alzheimer’s disease: The PREVENT study.

Ritchie K, Carrière I, Su L, O’Brien JT, Lovestone S, Wells K, Ritchie CW.
Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2017
10.1016/j.jalz.2017.02.008

Researchers analysed the results from PREVENT participants on various memory and thinking assessments. They found performance on particular spatial and navigation based tasks may be useful in differentiating between those deemed at high or low risk for later life dementia.

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At, with and beyond risk: expectations of living with the possibility of future dementia.

Milne R, Diaz A, Badger S, Bunnik E, Fauria K, Wells K.
Sociology of health & illness. 2017.
10.1111/1467-9566.12731

Focus groups were held with PREVENT participants to develop discussions around disclosure of dementia risk.

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Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer’s disease.

Stefaniak JD, Su L, Mak E, Sheikh-Bahaei N, Wells K, Ritchie K, Waldman A, Ritchie CW, O’Brien JT.
Alzheimer’s & Dementia. 2017
10.1016/j.jalz.2017.08.017

Studying brain scans of PREVENT participants, the health of the small blood vessels that feed the brain did not appear to significantly differ between those considered at higher risk of Alzheimer’s disease based on genetic factors compared to those at lower risk.

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The PREVENT research programme–a novel research programme to identify and manage midlife risk for dementia: the conceptual framework.

Ritchie CW, Wells K, Ritchie K.
International Review of Psychiatry. 2013
10.3109/09540261.2013.869195

This article outlines the vision of the PREVENT study and how, through in depth study of people in their mid-life, PREVENT can generate novel evidence to inform future interventional trials and improve future care.

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The PREVENT study: a prospective cohort study to identify mid-life biomarkers of late-onset Alzheimer’s disease.

Ritchie CW, Ritchie K.

BMJ open. 2012

10.1136/bmjopen-2012-001893

This publication describes the importance of developing a study to investigate markers present in midlife that could identify people at increased risk for later life dementia.

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Fundraising to Support New Genetic Analysis

Edinburgh Marathon Festival relay team
Edinburgh Marathon Festival relay team

Our wonderful CDP runners took to the streets once again for this year’s Edinburgh Marathon Festival to tackle the 5k, 10k and marathon relay. All their hard work and excellent fundraising will make a huge contribution towards growing the PREVENT Dementia Research Programme.

In addition to our sponsored runners we are extremely grateful to the University of Edinburgh Estates Department who held an excellent bake sale series raising a staggering £2000 for the Centre. In a fantastic year of fundraising our volunteers have generated a total of over £7000 and counting!

These funds will help establish the PREVENT Dementia Genetics Core. This exciting new initiative will be led by Dr Riccardo Marioni at the University of Edinburgh who described the importance of the project:

“PREVENT Dementia is an internationally leading clinical study of Alzheimer’s dementia prevention but currently lacks a genetics and genomics element to help (1) inform our mechanistic understanding of Alzheimer’s and (2) further improve risk prediction.

University of Edinburgh Estates team Bake Sale
University of Edinburgh Estates team hosted a series of successful Bake Sales

We have recently applied for grant funding, which if successful, will be used in tandem with your fundraising efforts to support the collection of multiple biological measures, including genetics, epigenetics (chemical changes that turn genes on/off), and protein levels to complement the existing neurologic, biologic, cognitive, and brain imaging data in PREVENT.”

 

Clare Dolan with her Edinburgh 5k medal
Clare Dolan of the CDP ran the Edinburgh 5k for PREVENT Dementia

Integral to the value of this new analysis is the desire to share world leading, novel information with the global dementia research community.

“We intend to make these data accessible to researchers from around the world. This open science policy will promote collaboration with national and international researchers, accelerating progress towards our common goal of defeating dementia.”

The PREVENT Dementia project thrives on contributions made from its generous supporters and with more events planned in the coming months we are excited to see how this globally important study progresses.

Thank you so much to all our fantastic fundraisers, we are thrilled and humbled by the amazing support the project has received so far. With your help we can begin to understand the very earliest brain changes that occur in Alzheimer’s disease and this knowledge will power our ultimate goal of preventing dementia.

To find out more about our runners and to support the team see our JustGiving page.