Lucy E Stirland , Sarah Gregory, Tom C Russ, Craig W Ritchie, Graciela Muniz-Terrera
Journal of Comorbidity. 2020
There is evidence to suggest that brain health is associated with multimorbidity, polypharmacy, depression and anxiety. This study aimed to investigate the interactions between these four-potential dementia-risk factors (depression, anxiety, multimorbidity and polypharmacy) at mid-life.
By analysing data from our London site’s baseline measures, we discovered that having more chronic physical conditions (multimorbidity) was associated with both depression and anxiety in midlife. However, taking more medications (polypharmacy) was only associated with depression, not anxiety.
These findings highlight an interaction between physical health, medication and mental health at midlife. By following participants further over time and evaluating this interaction we may be able to use this information to inform mental and physical health strategies that may possibly prevent dementia in later life.
Sarah Gregory, Katie Wells, Kate Forysth, Cate Latto, Helen Szyra, Stina Saunders, Craig W Ritchie, Richard Milne
Dementia Journal. 2018
Milne R, Bunnik E, Diaz A, Richard E, Badger S, Gove D, Georges J, Fauria K, Molinuevo JL, Wells K, Ritchie C.
Journal of Alzheimer’s Disease. 2018
PREVENT participants took part in organised group discussions around the benefits, harms and rights of an individual finding out information from biological measurements that may inform their personal risk of Alzheimer’s disease.Read More
Focus groups featuring PREVENT participants as well as people living with dementia were held to establish the attitudes and desires of those individuals for who disclosure of such risk information is most pertinent. This publication summarises the opinions voiced in those group discussions around areas such as how best to clearly disclose information and the type of support that should be made available after learning personalised results.
Milne R, Diaz A, Badger S, Bunnik E, Fauria K, Wells K.
Sociology of health & illness. 2017.
Focus groups were held with PREVENT participants to develop discussions around disclosure of dementia risk.Read More
To explore these types of questions researchers held focus groups with PREVENT participants to gather opinion on the consequences of these new topics. The discussions centred around the groups expectations on discovering test results that may have implications for risk of future dementia. The three key areas under discussion were; ‘Living At Risk’ – taking proactive steps to reduce risk, ‘Living With Risk’ – maximising cognitive health and accessing healthcare services and ‘Living Beyond Risk’ – planning for later life and adjustment to symptoms.
Ritchie CW, Wells K, Ritchie K.
International Review of Psychiatry. 2013
This article outlines the vision of the PREVENT study and how, through in depth study of people in their mid-life, PREVENT can generate novel evidence to inform future interventional trials and improve future care.Read More
The authors provide a detailed breakdown of the main aims of the PREVENT programme and introduce the methods used to collect the wide range of information from volunteers. They speculate how knowledge gained from PREVENT and other similar studies can shape future prevention strategies to delay or halt the progression of Alzheimer’s disease.
Ritchie CW, Ritchie K.
BMJ open. 2012
This publication describes the importance of developing a study to investigate markers present in midlife that could identify people at increased risk for later life dementia.Read More