Mario A. Parra, Graciela Muniz-Terrera, Samuel O. Danso, Karen Ritchie, Craig W Ritchie.
Alzheimer’s & Dementia (2021)
DOI: https://doi/epdf/10.1002/alz.055104
Summary
The study assessed relational (face-name) and conjunctional (object-colour) memory markers in 183 participants from the PREVENT Dementia programme. Conjunctive measures included: the 4 Mountains test, Virtual reality supermarket task, name-face association test and the relational measure: the visual short term memory binding test were used to assess cognition. There were no significant differences in performance across different risk groups.
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W. Ritchie, Li Su, Graciela Muniz-Terrera & John T. O’Brien
Journal of Neurology. 2021
DOI: https://doi.org/10.1007/s00415-020-10383-8
Summary
Cardiovascular factors have a strong association with Alzheimer’s disease (AD) and brain atrophy. However, until recently, there has been limited longitudinal research in cognitive healthy middle-aged adults investigating these links. A recent PREVENT Dementia study used data from 167 participants in the PREVENT London cohort, to investigate associations between the CAIDE (Cardiovascular Risk Factors, Aging, and Dementia) score and structural MRI scans at both baseline and 2-year follow up. Participants in the high-risk group (i.e., those with a CAIDE score above 6) were on average, found to have a greater rate of brain atrophy. However, to identify the specific regions and structures driving this atrophy pattern, additional analysis was conducted using voxel based morphometry (VBM).
Claire Lancaster, Ivan Koychev, Jasmine Blane, Amy Chinner, Christopher, Chatham, Kirsten Taylor, Chris Hinds
Journal of Clinical and Experimental Neuropsychology. 2019
DOI: https://doi.org/10.1080/13803395.2020.1714551
Sofia de la Fuente Garcia, Craig W. Ritchie, and Saturnino Luz
BMJ Open. 2019
DOI: 10.1136/bmjopen-2018-026254
This publication lays out plans for the PREVENT Elicitation of Dialogues (PREVENT-ED) substudy. This project aims to analyse specific features of speech during conversation with PREVENT participants. The researchers seek to determine if there are any associations between changes in spoken dialogue and other risk factors for Alzheimer’s disease. Ultimately they want to know whether such dialogue analysis could be useful in screening for early stages of disease.
Karen Ritchie, Isabelle Carriere, David Howett, Li Su, Michael Hornberger, John T. O’Brien, Craig W. Ritchie and Dennis Chan.
Journal of Alzheimer’s Disease 65 (2018)
10.3233/JAD-180432
Ritchie K, Carrière I, Su L, O’Brien JT, Lovestone S, Wells K, Ritchie CW.
Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2017
10.1016/j.jalz.2017.02.008
Researchers analysed the results from PREVENT participants on various memory and thinking assessments. They found performance on particular spatial and navigation based tasks may be useful in differentiating between those deemed at high or low risk for later life dementia.
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