Mak E, Gabel S, Mirette H, Su L, Williams GB, Waldman A, Wells K, Ritchie K, Ritchie C, O’Brien J.
Ageing research reviews. 2017
Ritchie K, Carrière I, Berr C, Amieva H, Dartigues JF, Ancelin ML, Ritchie CW.
The Journal of clinical psychiatry. 2016
Ritchie K, Carrière I, Ritchie CW, Berr C, Artero S, Ancelin ML.
Milne R, Bunnik E, Diaz A, Richard E, Badger S, Gove D, Georges J, Fauria K, Molinuevo JL, Wells K, Ritchie C.
Journal of Alzheimer’s Disease. 2018
PREVENT participants took part in organised group discussions around the benefits, harms and rights of an individual finding out information from biological measurements that may inform their personal risk of Alzheimer’s disease.Read More
Focus groups featuring PREVENT participants as well as people living with dementia were held to establish the attitudes and desires of those individuals for who disclosure of such risk information is most pertinent. This publication summarises the opinions voiced in those group discussions around areas such as how best to clearly disclose information and the type of support that should be made available after learning personalised results.
Ritchie K, Carrière I, Su L, O’Brien JT, Lovestone S, Wells K, Ritchie CW.
Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2017
Researchers analysed the results from PREVENT participants on various memory and thinking assessments. They found performance on particular spatial and navigation based tasks may be useful in differentiating between those deemed at high or low risk for later life dementia.Read More
It is likely that traditional memory tests such as those used in memory clinic or in drug trials involving participants with established dementia may not be sensitive enough to identify the very earliest subtle changes in brain health. In this report the authors suggest that volunteers deemed at greater risk for dementia based on factors such as genetics and cardiovascular health, seemed to perform slightly worse on certain tasks, principally those which involved detailed spatial and navigation skills.
This initial data came from a relatively small number of the very first volunteers to enter the study. The results also come from only the first study visit and so capture only one snapshot in time. Whilst these findings alone are not enough to inform any one individual’s risk profile they do generate interesting areas to focus on when following participants throughout the duration of the study.