Lucy E Stirland , Sarah Gregory, Tom C Russ, Craig W Ritchie, Graciela Muniz-Terrera
Journal of Comorbidity. 2020
10.1177/1471301218789307
Summary
There is evidence to suggest that brain health is associated with multimorbidity, polypharmacy, depression and anxiety. This study aimed to investigate the interactions between these four-potential dementia-risk factors (depression, anxiety, multimorbidity and polypharmacy) at mid-life.
Claire Lancaster, Ivan Koychev, Jasmine Blane, Amy Chinner, Christopher, Chatham, Kirsten Taylor, Chris Hinds
Journal of Clinical and Experimental Neuropsychology. 2019
DOI: https://doi.org/10.1080/13803395.2020.1714551
Maria-Eleni Dounavi, Elijah Mak, Katie Wells, Karen Ritchie, Craig W. Ritchie, Li Su, John T.O’ Brien
Neurobiology of Ageing. 2020
DOI: https://doi.org/10.1016/j.neurobiolaging.2020.03.006
Summary
In this study, we found that participants with an APOEe4 genotype (a known genetic risk factor for dementia) were more likely to have a smaller hippocampal molecular layer, and this change was apparent at both the baseline and 2-year follow up.
Together with previous findings, it appears that the molecular layer may be one of the first areas to show vulnerability to the pathological hallmarks of Alzheimer’s. However, it was noted that differences in the molecular layer were not significantly related to dementia risk defined by family history or cardiovascular factors.
John T O’Brien, Michael J Firbank, Karen Ritchie,, Katie Wells, Guy B Williams, Craig W Ritchie, Li Su
Journal of Neurology, Neurosurgery & Psychiatry. 2019
Individuals with a higher likelihood of developing Alzheimer’s disease dementia in the future, as predicted by their mid-life CAIDE score, show more shrinkage of brain volume, measured over the course of two years.
Sofia de la Fuente Garcia, Craig W. Ritchie, and Saturnino Luz
BMJ Open. 2019
DOI: 10.1136/bmjopen-2018-026254
This publication lays out plans for the PREVENT Elicitation of Dialogues (PREVENT-ED) substudy. This project aims to analyse specific features of speech during conversation with PREVENT participants. The researchers seek to determine if there are any associations between changes in spoken dialogue and other risk factors for Alzheimer’s disease. Ultimately they want to know whether such dialogue analysis could be useful in screening for early stages of disease.
